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For example, milk at the end of a feed (hindmilk) contains considerably more fat than foremilk and may concentrate fat-soluble drugs.Transfer of drugs into breast milk is most commonly described quantitatively using the milk to plasma (M/P) concentration ratio.
Many mothers are required to use drugs during breastfeeding.
Sometimes, that drowsiness is why people take the drugs, and a little sedation might sound benign.
But if your brain is older, or otherwise vulnerable, don’t underestimate these drugs.
The accuracy of this value is improved if it is based on the area under the concentration-time curves (AUC) of the drug in maternal milk and plasma (M/P (L/kg/day) The volume of milk ingested by infants is commonly estimated as 0.15L/kg/day.
The infant dose (mg/kg) can then be expressed as a percentage of the maternal dose (mg/kg).